Sentinel Node Total Tumour Load As a Predictive Factor for Non-Sentinel Node Status in Early Breast Cancer Patients – The porttle study

OSNA is a molecular assay for the detection of sentinel node metastasis. TTL emerged as a concept that seems to accurately predict the status of the NSN. Authors tried to confirm this motion. This is a retrospective and multicentric study that analyzed 2164 patients, 579 of whom had positive SN and completion AD. Logistic regression models were performed in order to identify a suitable cutoff to identify patients who benefit from AD. Univariate and multivariate regression analysis showed a relationship between TTL>30000 and the presence of NSN metastasis (OR 2.84, CI 1.99-4.08, p < 0.001). Logistic regression indicated that the cutoff of 30000 copies/μL better discriminates patients with NSN positivity and allows wide use of these criteria. This cutoff value may safely assist clinicians and patients to decide to proceed or not with an AD.

Keywords

HCC CIR Adult Aged Breast Neoplasms / metabolism Aged, 80 and over Breast Neoplasms / pathology* Humans Female Breast Neoplasms / surgery Middle Aged Carcinoma, Ductal, Breast / metabolism Carcinoma, Ductal, Breast / secondary* Carcinoma, Ductal, Breast / surgery Carcinoma, Lobular / metabolism Carcinoma, Lobular / secondary* Carcinoma, Lobular / surgery Follow-Up Studies Lymph Nodes / metabolism Lymph Nodes / pathology* Lymph Nodes / surgery Lymphatic Metastasis Prognosis Receptor, ErbB-2 / metabolism Receptors, Estrogen / metabolism Receptors, Progesterone / metabolism Young Adult Sentinel Lymph Node Biopsy* Retrospective Studies