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Neuromyelitis Optica in Portugal (NEMIPORT) - A Multicentre Study

2015Journal article Open access
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dc.contributor.authorDomingos, J
dc.contributor.authorIsidoro, L
dc.contributor.authorFigueiredo, R
dc.contributor.authorBrum, M
dc.contributor.authorCapela, C
dc.contributor.authorBarros, P
dc.contributor.authorSantos, E
dc.contributor.authorMacário, MC
dc.contributor.authorPinto Marques, J
dc.contributor.authorPedrosa, R
dc.contributor.authorVale, J
dc.contributor.authorSá, MJ
dc.date.accessioned2015-06-12T15:02:43Z
dc.date.available2015-06-12T15:02:43Z
dc.date.issued2015
dc.description.abstractBACKGROUND: Neuromyelitis Optica (NMO) is an inflammatory demyelinating disease of the CNS. There have been few epidemiologic studies on NMO, none in Portugal. OBJECTIVE: To analyze the clinical, biological and MRI characteristics from a cohort of Portuguese patients who fulfilled the Wingerchuk 2006 NMO/NMOSD criteria. To identify and characterize those who had concomitant autoimmune disease or circulating autoantibodies. METHODS: We performed an observational, retrospective, multicenter study in 5 Hospital Centers in Portugal. RESULTS: Sixty-seven patients fulfilled the inclusion criteria. They were mainly Caucasian, 55 female. Median age at onset was 32.0 years and mean follow-up 7.4±6.0 years. Twenty-one patients were definite NMO and optic neuritis (ON) the most frequent initial presentation. Forty-six were classified as NMO spectrum disorders. The main subtypes were recurrent ON and single longitudinally extensive transverse myelitis. Twenty-four patients had positive AQP4-IgG. Twenty-three had other circulating autoantibodies. Fifteen out of 67 patients had concomitant autoimmune disease. There was a significant correlation between the presence of autoimmune disease and the positivity for AQP4-IgG. Five patients died, all definite NMO. CONCLUSION: This is the first study about this rare disease in Portugal. Demographic features were similar to other studies. The existence of concomitant autoimmune disease was significantly associated with seropositivity for AQP4-IgG.por
dc.identifier.citationClin Neurol Neurosurg. 2015 Jul;134:79-84por
dc.identifier.urihttp://hdl.handle.net/10400.17/2228
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherElsevierpor
dc.subjectHSAC OFTpor
dc.subjectAge of Onsetpor
dc.subjectAquaporin 4/immunologypor
dc.subjectAutoantibodies/immunologypor
dc.subjectAutoimmune Diseases/epidemiologypor
dc.subjectAutoimmune Diseases/immunologypor
dc.subjectBrain/pathology
dc.subjectComorbidity
dc.subjectCohort Studies
dc.subjectFollow-Up Studies
dc.subjectImmunoglobulin G/immunology
dc.subjectMagnetic Resonance Imaging
dc.subjectNeuromyelitis Optica/epidemiology
dc.subjectNeuromyelitis Optica/immunology
dc.subjectNeuromyelitis Optica/pathology
dc.subjectOptic Neuritis/epidemiology
dc.subjectOptic Neuritis/immunology
dc.subjectOptic Neuritis/pathology
dc.subjectPortugal/epidemiology
dc.subjectRetrospective Studies
dc.subjectSex Distribution
dc.titleNeuromyelitis Optica in Portugal (NEMIPORT) - A Multicentre Studypor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage84por
oaire.citation.startPage79por
oaire.citation.titleClinical Neurology and Neurosurgerypor
rcaap.rightsopenAccesspor
rcaap.typearticlepor

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