Loading...
| Name: | Description: | Size: | Format: | |
|---|---|---|---|---|
| 350.94 KB | Adobe PDF |
Advisor(s)
Abstract(s)
Background and purpose: Diffusion tensor imaging (DTI) parameters are markers of cerebral lesion in some diseases. In patients with acute subarachnoid hemorrhage (SAH), we investigated whether DTI parameters measured at <72 hours might be associated with delayed cerebral ischemia (DCI) and with poor functional outcome at 3 months (modified Rankin Scale score ≥3).
Methods: DTI was performed in a prospective cohort of 60 patients with nontraumatic SAH at <72 hours. Association of fractional anisotropy and apparent diffusion coefficient values at <72 hours with the occurrence of DCI and outcome at 3 months was evaluated with logistic regression models, adjusting for known predictors of prognosis.
Results: At <72 hours after SAH, fractional anisotropy values at the cerebellum were associated with DCI occurrence (78% less odds of DCI for each 0.1 increase in fractional anisotropy; P=0.019). Early apparent diffusion coefficient values were not associated with DCI. After adjusting for confounding variables, an increase of 10 U in apparent diffusion coefficient at the frontal centrum semiovale corresponded to 15% increased odds of poor outcome (P=0.061).
Conclusions: DTI parameters at <72 hours post-SAH are independently associated with the occurrence of DCI and functional outcome. These preliminary results suggest the role of DTI parameters as surrogate markers of prognosis in nontraumatic SAH.
Description
Keywords
HSJ NRAD HSJ NEU CHLC CINV Adult Aged Female Male Humans Middle Aged 80 and over Brain Ischemia / diagnostic imaging* Brain Ischemia / physiopathology Cohort Studies Diffusion Tensor Imaging / trends* Early Diagnosis Predictive Value of Tests Prospective Studies Recovery of Function / physiology* Risk Factors Subarachnoid Hemorrhage / diagnostic imaging* Subarachnoid Hemorrhage / physiopathology Time Factors Treatment Outcome
Citation
Stroke . 2017 Aug;48(8):2091-2097.
Publisher
American Heart Association