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Early Prediction of Delayed Ischemia and Functional Outcome in Acute Subarachnoid Hemorrhage: Role of Diffusion Tensor Imaging.

2017-08Text Open access
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dc.contributor.authorFragata, Isabel
dc.contributor.authorAlves, Marta
dc.contributor.authorPapoila, Ana Luísa
dc.contributor.authorNunes, Ana Paiva
dc.contributor.authorFerreira, Patrícia
dc.contributor.authorCanto-Moreira, Nuno
dc.contributor.authorCanhão, Patrícia
dc.date.accessioned2025-08-01T15:28:34Z
dc.date.available2025-08-01T15:28:34Z
dc.date.issued2017-08
dc.description.abstractBackground and purpose: Diffusion tensor imaging (DTI) parameters are markers of cerebral lesion in some diseases. In patients with acute subarachnoid hemorrhage (SAH), we investigated whether DTI parameters measured at <72 hours might be associated with delayed cerebral ischemia (DCI) and with poor functional outcome at 3 months (modified Rankin Scale score ≥3). Methods: DTI was performed in a prospective cohort of 60 patients with nontraumatic SAH at <72 hours. Association of fractional anisotropy and apparent diffusion coefficient values at <72 hours with the occurrence of DCI and outcome at 3 months was evaluated with logistic regression models, adjusting for known predictors of prognosis. Results: At <72 hours after SAH, fractional anisotropy values at the cerebellum were associated with DCI occurrence (78% less odds of DCI for each 0.1 increase in fractional anisotropy; P=0.019). Early apparent diffusion coefficient values were not associated with DCI. After adjusting for confounding variables, an increase of 10 U in apparent diffusion coefficient at the frontal centrum semiovale corresponded to 15% increased odds of poor outcome (P=0.061). Conclusions: DTI parameters at <72 hours post-SAH are independently associated with the occurrence of DCI and functional outcome. These preliminary results suggest the role of DTI parameters as surrogate markers of prognosis in nontraumatic SAH.eng
dc.identifier.citationStroke . 2017 Aug;48(8):2091-2097.
dc.identifier.doi10.1161/STROKEAHA.117.016811.
dc.identifier.pmc28667021
dc.identifier.pmid28667021
dc.identifier.urihttp://hdl.handle.net/10400.17/5130
dc.language.isoeng
dc.peerreviewedyes
dc.publisherAmerican Heart Association
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/
dc.subjectHSJ NRAD
dc.subjectHSJ NEU
dc.subjectCHLC CINV
dc.subjectAdult
dc.subjectAged
dc.subjectFemale
dc.subjectMale
dc.subjectHumans
dc.subjectMiddle Aged
dc.subject80 and over
dc.subjectBrain Ischemia / diagnostic imaging*
dc.subjectBrain Ischemia / physiopathology
dc.subjectCohort Studies
dc.subjectDiffusion Tensor Imaging / trends*
dc.subjectEarly Diagnosis
dc.subjectPredictive Value of Tests
dc.subjectProspective Studies
dc.subjectRecovery of Function / physiology*
dc.subjectRisk Factors
dc.subjectSubarachnoid Hemorrhage / diagnostic imaging*
dc.subjectSubarachnoid Hemorrhage / physiopathology
dc.subjectTime Factors
dc.subjectTreatment Outcome
dc.titleEarly Prediction of Delayed Ischemia and Functional Outcome in Acute Subarachnoid Hemorrhage: Role of Diffusion Tensor Imaging.eng
dc.typetext
dspace.entity.typePublication
oaire.citation.endPage2097
oaire.citation.issue8
oaire.citation.startPage2091
oaire.citation.titleStroke
oaire.citation.volume48
oaire.versionhttp://purl.org/coar/version/c_970fb48d4fbd8a85

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