Orbital Metastasis from an Occult Breast Carcinoma (T0, N1, M1)

Pinto Proença, R; Fernandes, J; Burnier, M; Proença, R

http://hdl.handle.net/10400.17/4429

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Abstract(s)

The authors report a case of an orbital metastasis from an occult breast carcinoma. A 66-year-old woman presented with a growing left orbital tumour. Orbital CT scan was consistent with lymphoma. However, ocular pathology revealed small neoplastic cells showing an 'indian file pattern' suggestive of metastatic carcinoma and immunohistochemistry was positive for CK7, CK CAM5.2 and oestrogen receptor. A systemic evaluation was then performed with mammogram, breast ultrasound and MRI considered normal. An exhaustive systemic evaluation revealed multiple bone lesions, a right axillary lymph node lesion, which presented the same pattern on pathology and immunohistochemistry, with no evidence of a primary tumour. A diagnosis of a metastatic lobular carcinoma of the breast (T0, N1, M1) was made and the patient was started on chemotherapy and adjuvant hormonal therapy.

Keywords

CHLC OFT Aged Female Humans Biomarkers, Tumor Biopsy Breast Neoplasms / diagnostic imaging Breast Neoplasms / pathology* Carcinoma, Lobular / diagnostic imaging Carcinoma, Lobular / secondary* Combined Modality Therapy Eye Neoplasms / diagnostic imaging Eye Neoplasms / pathology Eye Neoplasms / secondary* Eye Neoplasms / therapy Keratin-7 / analysis Magnetic Resonance Imaging Mammography Neoplasms, Unknown Primary / diagnostic imaging Neoplasms, Unknown Primary / pathology* Neoplasms, Unknown Primary / therapy Tomography, X-Ray Computed Ultrasonography Whole Body Imaging