Publication
Correlação da Variação dos Níveis de NT-ProBNP com a Modificação da Capacidade Funcional em Doentes com Insuficiência Cardíaca Crónica
| dc.contributor.author | Fernandes, RM | |
| dc.contributor.author | Feliciano, J | |
| dc.contributor.author | Soares, RM | |
| dc.contributor.author | Mamede, A | |
| dc.contributor.author | Ramos, R | |
| dc.contributor.author | Miranda, F | |
| dc.contributor.author | Silva, S | |
| dc.contributor.author | Timóteo, AT | |
| dc.contributor.author | Abreu, A | |
| dc.contributor.author | Cruz Ferreira, R | |
| dc.date.accessioned | 2011-04-08T16:45:07Z | |
| dc.date.available | 2011-04-08T16:45:07Z | |
| dc.date.issued | 2007 | |
| dc.description.abstract | OBJECTIVE: We set out to evaluate whether changes in N-terminal pro-brain natriuretic peptide (proBNP) can predict changes in functional capacity, as determined by cardiopulmonary exercise testing (CPET), in patients with chronic heart failure (CHF) due to dilated cardiomyopathy (DCM). METHODS: We studied 37 patients with CHF due to DCM, 81% non-ischemic, 28 male, who performed symptom-limited treadmill CPET, with the modified Bruce protocol, in two consecutive evaluations, with determination of proBNP after 10 minutes rest prior to CPET. The time between evaluations was 9.6+/-5.5 months, and age at first evaluation was 41.1+/-13.9 years (21 to 67). RESULTS IN THE FIRST AND SECOND EVALUATIONS RESPECTIVELY WERE: NYHA functional class >II 51% and 16% (p<0.001), sinus rhythm 89% and 86.5% (NS), left ventricular ejection fraction 24.9+/-8.9% and 26.6+/-8.6% (NS), creatinine 1.03+/-0.25 and 1.09+/-0.42 mg/dl (NS), taking ACE inhibitors or ARBs 94.5% and 100% (NS), beta-blockers 73% and 97.3% (p<0.001), and spironolactone 89% and 89% (NS). We analyzed the absolute and percentage variation (AV and PV) in peak oxygen uptake (pVO2--ml/kg/min) and proBNP (pg/ml) between the two evaluations. RESULTS: (1) pVO2 AV: -17.4 to 15.2 (1.9+/-5.7); pVO2 PV: -56.1 to 84% (11.0+/-25.2); proBNP AV: -12850 to 5983 (-778.4+/-3332.5); proBNP PV: -99.0 to 379.5% (-8.8+/-86.3); (2) The correlations obtained--r value and p value [r (p)]--are shown in the table below; (3) We considered that a coefficient of variation of pVO2 PV of >10% represented a significant change in functional capacity. On ROC curve analysis, a proBNP PV value of 28% showed 80% sensitivity and 79% specificity for pVO2 PV of >10% (AUC=0.876, p=0.01, 95% CI 0.75 to 0.99). CONCLUSIONS: In patients with CHF due to DCM, changes in proBNP values correlate with variations in pVO2, as assessed by CPET. However, our results suggest that only a proBNP PV of >28% predicts a significant change in functional capacity. | |
| dc.identifier.citation | Rev Port Cardiol 2007; 26 (12): 1329-1344 | por |
| dc.identifier.uri | http://hdl.handle.net/10400.17/89 | |
| dc.language.iso | por | por |
| dc.publisher | Sociedade Portuguesa de Cardiologia | por |
| dc.subject | Adulto | por |
| dc.subject | Idoso | por |
| dc.subject | Doença Crónica | por |
| dc.subject | Insuficiência Cardíaca | por |
| dc.subject | Oxigénio | por |
| dc.subject | Estudos Prospectivos | |
| dc.subject | Fragmentos de Peptídeos | |
| dc.title | Correlação da Variação dos Níveis de NT-ProBNP com a Modificação da Capacidade Funcional em Doentes com Insuficiência Cardíaca Crónica | por |
| dc.title.alternative | Correlation Between NT-proBNP Values and Changes in Functional Capacity in Patients with Chronic Heart Failure | |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 1344 | por |
| oaire.citation.startPage | 1329 | por |
| oaire.citation.title | Revista Portuguesa de Cardiologia | por |
| rcaap.rights | openAccess | por |
| rcaap.type | article | por |