Methadone Intoxication in a Child: Toxic Encephalopathy?

Anselmo, M; Campos Rainho, A; Vale, MC; Estrada, J; Valente, R; Correia, M; Vieira, JP; Barata, D

http://hdl.handle.net/10400.17/2343

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Abstract(s)

Methadone is used in the treatment of opioid addiction. Acute intoxication can lead to severe consequences and can even be lethal. In several case reports and small series, a presumably toxic leukoencephalopathy is described resulting from inhalation of heroin. We present the case of a 3-year-old boy who ingested methadone accidentally. In a coma with acute obstructive hydrocephalus owing to massive cerebellar edema and supratentorial lesions, he was successfully treated with methylprednisolone and cerebrospinal fluid external drainage. To our knowledge, this is the first report of an encephalopathy associated with synthetic opioid intoxication.

Keywords

Analgesics, Opioid/poisoning Brain Diseases/chemically induced Brain Diseases/pathology Brain Diseases/therapy Methadone/poisoning Neurotoxicity Syndromes/etiology Neurotoxicity Syndromes/therapy Child, Preschool Case Reports HDE NEU PED HDE UCI PED

URI

http://hdl.handle.net/10400.17/2343

Citation

J Child Neurol. 2006 Jul;21(7):618-20.

Publisher

Sage Publications

Collections

NEU PED - Artigos
UCI PED - Artigos

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