Pneumocystosis Pneumonia: A Comparison Study Between HIV and Non-HIV Immunocompromised Patients

Rego de Figueiredo, I; Vieira Alves, R; Drummond Borges, D; Torres, M; Lourenço, F; Antunes, AM; Gruner, H; Panarra, A

http://hdl.handle.net/10400.17/3317

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Authors

Rego de Figueiredo, I

Abstract(s)

Pneumocystis pneumonia (PCP) is caused by the fungus Pneumocystis jirovecii, and its incidence has been on the rise in immunosuppressed patients without HIV. We performed a cross sectional study in patients with PCP and assessed demographic, clinical presentation and outcome measures such as mechanical ventilation and mortality differences between HIV and non-HIV patients. The two groups were statistically significantly different, with the HIV group being younger (45.5 years vs 55.9 years, p-value 0.001) and mostly composed of male patients (69% vs 31%, p-value <0.001). Also, the HIV patients had higher percentage of respiratory complaints (90% vs 68%, p-value 0.02) and lactate dehydrogenase elevation (73% vs 40%, p-value 0.001). In contrast, non-HIV patients had worse outcomes with higher incidence of invasive mechanical ventilation (23% vs 46%, p-value 0.005) and in-hospital mortality (13% vs 37%, p-value 0.002). These results reflect the literature and should raise awareness to a potentially fatal medical situation of increasing incidence.

Keywords

HCC MED HCC INF Comorbidity Cross-Sectional Studies HIV Infections/epidemiology HIV Infections/immunology Hospital Mortality Immunocompromised Host L-Lactate Dehydrogenase/blood Pneumonia, Pneumocystis/epidemiology Pneumonia, Pneumocystis/immunology Pneumonia, Pneumocystis/mortality Portugal/epidemiology Respiration, Artificial/statistics & numerical data Retrospective Studies