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Balance Between Maternal Antiviral Response and Placental Transfer of Protection in Gestational SARS-CoV-2 Infection

2023Journal article Open access
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dc.contributor.authorGonçalves, J
dc.contributor.authorMelro, M
dc.contributor.authorAlenquer, M
dc.contributor.authorAraújo, C
dc.contributor.authorCastro-Neves, J
dc.contributor.authorAmaral-Silva, D
dc.contributor.authorFerreira, F
dc.contributor.authorRamalho, JS
dc.contributor.authorCharepe, N
dc.contributor.authorSerrano, F
dc.contributor.authorPontinha, C
dc.contributor.authorAmorim, MJ
dc.contributor.authorSoares, H
dc.date.accessioned2024-08-13T09:14:15Z
dc.date.available2024-08-13T09:14:15Z
dc.date.issued2023
dc.description.abstractThe intricate interplay between maternal immune response to SARS-CoV-2 and the transfer of protective factors to the fetus remains unclear. By analyzing mother-neonate dyads from second and third trimester SARS-CoV-2 infections, our study shows that neutralizing antibodies (NAbs) are infrequently detected in cord blood. We uncovered that this is due to impaired IgG-NAb placental transfer in symptomatic infection and to the predominance of maternal SARS-CoV-2 NAbs of the IgA and IgM isotypes, which are prevented from crossing the placenta. Crucially, the balance between maternal antiviral response and transplacental transfer of IgG-NAbs appears to hinge on IL-6 and IL-10 produced in response to SARS-CoV-2 infection. In addition, asymptomatic maternal infection was associated with expansion of anti-SARS-CoV-2 IgM and NK cell frequency. Our findings identify a protective role for IgA/IgM-NAbs in gestational SARS-CoV-2 infection and open the possibility that the maternal immune response to SARS-CoV-2 infection might benefit the neonate in 2 ways, first by skewing maternal immune response toward immediate viral clearance, and second by endowing the neonate with protective mechanisms to curtail horizontal viral transmission in the critical postnatal period, via the priming of IgA/IgM-NAbs to be transferred by the breast milk and via NK cell expansion in the neonate.pt_PT
dc.description.versioninfo:eu-repo/semantics/publishedVersionpt_PT
dc.identifier.citationJCI Insight . 2023 Sep 8;8(17):e167140pt_PT
dc.identifier.doi10.1172/jci.insight.167140pt_PT
dc.identifier.urihttp://hdl.handle.net/10400.17/4979
dc.language.isoengpt_PT
dc.peerreviewedyespt_PT
dc.publisherAmerican Society for Clinical Investigationpt_PT
dc.subjectAntibodies, Neutralizingpt_PT
dc.subjectAntiviral Agentspt_PT
dc.subjectAsymptomatic Infectionspt_PT
dc.subjectCOVID-19pt_PT
dc.subjectFemalept_PT
dc.subjectImmunoglobulin Apt_PT
dc.subjectImmunoglobulin Gpt_PT
dc.subjectImmunoglobulin Mpt_PT
dc.subjectInfant, Newbornpt_PT
dc.subjectPlacentapt_PT
dc.subjectPregnancypt_PT
dc.subjectSARS-CoV-2pt_PT
dc.subjectMAC OBSpt_PT
dc.titleBalance Between Maternal Antiviral Response and Placental Transfer of Protection in Gestational SARS-CoV-2 Infectionpt_PT
dc.typejournal article
dspace.entity.typePublication
oaire.citation.issue17pt_PT
oaire.citation.startPagee167140pt_PT
oaire.citation.titleJCI Insightpt_PT
oaire.citation.volume8pt_PT
rcaap.rightsopenAccesspt_PT
rcaap.typearticlept_PT

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