Intrahepatic Clear Cell Cholangiocarcinoma - An Uncommon Histologic Subtype: Case Report and Literature Review

Raimundo Fernandes, S; Baldaia, C; Pinto Marques, H; Tortosa, F; Ramalho, F

http://hdl.handle.net/10400.17/2730

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Authors

Raimundo Fernandes, S

Abstract(s)

Clear-cell cholangiocarcinoma is a very uncommon variant of cholangiocarcinoma with a largely unknown natural history and prognosis. We report a case of a 51-year-old previously healthy woman presenting with a large liver nodule found on routine imaging. Needle biopsy of the lesion suggested a non-hepatocellular carcinoma. After extensive workup for other primary neoplasms, the patient underwent a partial hepatectomy. Histopathology was compatible with a moderately differentiated clear-cell cholangiocarcinoma. There was no evidence of liver disease in the remaining tissue. The patient underwent chemotherapy and remains in clinical remission after two years.

Keywords

CHLC CHBPT Adenocarcinoma, Clear Cell/diagnosis Adenocarcinoma, Clear Cell/pathology Bile Duct Neoplasms/diagnosis Bile Duct Neoplasms/pathology Bile Ducts, Intrahepatic/pathology Cholangiocarcinoma/diagnosis Cholangiocarcinoma/pathology