Publication
Dabigatran-Related Nephropathy in a Patient with Undiagnosed IgA Nephropathy
| dc.contributor.author | Escoli, R | |
| dc.contributor.author | Santos, P | |
| dc.contributor.author | Andrade, S | |
| dc.contributor.author | Carvalho, F | |
| dc.date.accessioned | 2016-08-12T12:28:33Z | |
| dc.date.available | 2016-08-12T12:28:33Z | |
| dc.date.issued | 2015 | |
| dc.description.abstract | Dabigatran is a direct thrombin inhibitor used as an alternative to warfarin for long term anticoagulation. Warfarin-related nephropathy is an increasingly recognized entity, but recent evidence suggests that dabigatran can cause a WRN-like syndrome. We describe a case of a biopsy-proven anticoagulant nephropathy related to dabigatran in a patient with IgA nephropathy and propose that, despite the base glomerular disease, acute kidney injury was due to tubular obstruction by red blood cells and heme-associated tubular injury, and through a mechanism involving inhibition of anticoagulation cascade and barrier abnormalities caused by molecular mechanisms. | pt_PT |
| dc.identifier.citation | Case Rep Nephrol. 2015;2015:298261 | pt_PT |
| dc.identifier.doi | 10.1155/2015/298261 | pt_PT |
| dc.identifier.uri | http://hdl.handle.net/10400.17/2556 | |
| dc.language.iso | eng | pt_PT |
| dc.peerreviewed | yes | pt_PT |
| dc.publisher | Hindawi Publishing Corporation | pt_PT |
| dc.subject | HCC NEF | pt_PT |
| dc.subject | Dabigatran | pt_PT |
| dc.subject | Glomerulonephritis, IGA | pt_PT |
| dc.title | Dabigatran-Related Nephropathy in a Patient with Undiagnosed IgA Nephropathy | pt_PT |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 4 | pt_PT |
| oaire.citation.startPage | 298261 | pt_PT |
| oaire.citation.title | Case Reports in Nephrology | pt_PT |
| oaire.citation.volume | 2015 | pt_PT |
| rcaap.rights | openAccess | pt_PT |
| rcaap.type | article | pt_PT |