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- The Efficacy of Dupilumab Largely Exceeds the 6-Month Treat-to-target Goals: An Analysis in an Atopic Dermatitis Referral CenterPublication . Valente C; Figueira Vilela B; Paiva-Lopes MJ; Duarte B
- Ortho-Monitorizer: A Portable Device for Quantitative Monitoring of Temperature and Pressure in a 3D-Printed Upper Limb Orthosis.Publication . Antão, Matilde; Rodrigues, Inês; Quintão, Carla; Quaresma, CláudiaBackground: Adherence to wrist-hand orthoses in patients with musculoskeletal conditions, such as Carpal Tunnel Syndrome, is crucial for effective rehabilitation. However, objective methods for monitoring wear time and pressure distribution remain limited. Purpose: This study presents the Ortho-Monitorizer, a portable 3D-printed sensor-integrated device designed to provide real-time, quantitative monitoring of temperature and pressure in upper limb orthoses. The objective is to evaluate the system's feasibility in detecting patient adherence and identifying critical pressure points. Study design: A descriptive and cross-sectional study was conducted to develop and validate the device, including sensor integration and data acquisition. Methods: Using a 3D scanner and Fusion 360 software, the orthoses were customized and printed in thermoplastic polyurethane. Data from healthy participants (n = 55) and patients with Carpal Tunnel Syndrome (n = 2) were collected through the Ortho-Monitorizer's application, using six sensors (three temperature and three pressure sensors) placed at clinically relevant anatomical points. Data were acquired over five hand positions, and normal reference values were established. Results: Mean temperature values ranged between 29.5∘C and 32.5∘C, while pressure values varied from 0.00 MPa to 0.08 MPa across different hand positions. One CTS patient exhibited pressure values above normal thresholds in specific positions, correlating with discomfort and numbness reports. The device achieved a System Usability Scale (SUS) score of 86.8% (healthy participants) and 92.5% (CTS patients), indicating high usability and acceptance. Conclusions: The Ortho-Monitorizer provides a non-invasive, objective method for monitoring patient adherence to orthotic treatments. By offering real-time tracking of critical parameters, it enhances clinical decision-making and patient outcomes. Future research should explore wireless integration and long-term clinical validation to further optimize its applicability.
- Reconciliação Medicamentosa num Serviço de Urgência: um Processo de Melhoria ContínuaPublication . de Almeida Marinho Diniz, Ana Cristina; Pereira Borges Sousa, Anabela; Tartaglia Reis, Cláudia; Sardinha Vieira Ramos, Susana Maria; Máximo Barreiros, Paulo Mnuel; dos Santos Sousa, Paulo JorgeObjetivos: estruturar o plano de melhoria para a reconciliação da medicação num serviço de urgência português. Método: elaborou-se o projeto de melhoria com a metodologia Plan, Do, Act, Plan (PDSA), em um estudo observacional, descritivo, quantitativo. Na etapa Plan, participaram 282 pacientes admitidos em serviço de urgência, cujo familiar teve teleconsulta de Enfermagem; e 447 na etapa Study. Realizada a estruturação da teleconsulta com a técnica Identify, Situation, Background, Assessment e Recommendation (ISBAR); formação da equipe. Resultados: na prática habitual dos enfermeiros, identificaram-se 4,6% (n=13) discrepâncias não intencionais entre a prescrição e a medicação em uso no domicílio. Observou-se o aumento para 9,4% (n=42) de discrepâncias após a estruturação da teleconsulta, que passou a incluir as questões sobre a medicação habitual. A interrupção, sobretudo de medicamentos que atuam no sistema nervoso central, dose/frequência incorreta, foi a discrepância mais frequente, posteriormente corrigida. Conclusão: o estudo contribuiu para identificar/corrigir as falhas na reconciliação de medicação, a fim de evidenciar a importância da participação da Enfermagem e da família
- Assessment of Competencies of Clinical Research Professionals and Proposals to Improve Clinical Research in Portugal.Publication . Bogas, Mónica; Antas, Joana; Magalhães, Cátia; Revige, Mafalda; Guerra, Liliana; Ribeiro, Cheila; Eça, Rita Cunha; Nunes, Filipa; Lopes, Ana; Costa, Luís; Gonçalves, Mónica; Pedrosa, Jorge; Capela, Andreia; Gregório, Tiago; Dias, Patrícia; Alfaro, Tiago; Pais, Ana; Soares, Rui; Queirós, Ana; Torres, Tiago; Assis, Joana; Maia, Joana; Ferreira, Margarida; Horta, Luís; Carreiro, Rita; Almeida, João; Meireles, Maria João; Loução, Carla; António, Sofia; Lopes, Catarina; Coelho, Pedro; Costa, Rita; Santana, Margarida; Sousa, NunoBackground: Clinical studies are coordinated by multidisciplinary teams, which often lack adequate training and competencies. In this study, ROCHE and AICIB (Agency for Clinical Research and Biomedical Innovation) conducted a self-assessment survey aiming to evaluate the competency of clinical research professionals to conduct clinical research in Portugal and promote the identification of key actions to address priority gaps. Methods: Clinical research professionals from 10 Portuguese centres answered an electronic survey, adapted and translated from the Joint Task Force for Clinical Trial Competency (JTFCTC) framework. Representatives of the centres, ROCHE and AICIB held a meeting to discuss the survey results, identify priority gaps and propose recommendations. Results: A total of 109 participants answered the questionnaire with the following national geographical distribution: North (n = 46), Centre Region (n = 16), and Lisbon metropolitan area (n = 47). A considerable proportion were Investigators (44.0%) and had more than 10 years of experience (34.9%). The eight JTFCTC Domains scored under 60% in the level of knowledge, with Investigators achieving overall higher scores. To address these gaps, key actions were proposed, such as enhancing training and educational opportunities, fostering collaboration and networking, and investing in infrastructure and resources. Conclusion: This study was the first to assess clinical trial competency in Portugal, registering a high participation rate. The study highlights the need to develop a national plan of action, in a collaborative effort, between clinical research centres, universities, industry, regulatory authorities, national agencies, and patient organizations. This will not only contribute to elevate the quality of studies but also improve compliance with international standards, ultimately benefiting both researchers and patients.
- Estudo da Prevalência da Hipertensão Arterial em Crianças e Adolescentes na Região de Lisboa e Vale do Tejo.Publication . Simão, Carla; Glória, Joana; Torres Oliveira, Sara; Deuchande, Sofia; Abranches, Margarida; Correia, Susana; Nunes, Paula; Teodoro, Filomena; Saraiva, Duarte; Ferreira, Carmen; Rocha, Liliana; Teixeira, Ana; Oliveira, Paula; Mendes, Patrícia; Santos, Raquel; Sociedade Portuguesa de HipertensãoIntrodução: A hipertensão arterial (HTA) é um fator de risco importante de doença cardiovascular (DCV) em qualquer idade. Estima-se uma prevalência na criança de 3-5%. O conhecimento da sua prevalência permite adequar medidas de controlo, tratamento e prevenção, procurando diminuir a morbilidade e mortalidade associadas à DCV. Objetivos: Avaliar a prevalência da HTA em crianças e adolescentes em idade escolar e o efeito de variáveis sociodemográficas e somatométricas no perfil tensional. Metodologia: Estudo multicêntrico, observacional, prospetivo e transversal que decorreu entre 2016 e 2019. Amostra com crianças entre os 6 e 18 anos, residentes na região de Lisboa e Vale do Tejo. Realizada medição da pressão arterial (PA) pelo método oscilométrico, em ambiente escolar. A classificação do perfil tensional em PA normal, PA elevada (PAE) e hipertensão arterial (HTA), baseou-se nos critérios da ESH-2016. Registados género, idade, raça, escolaridade, peso e estatura. Realizada análise estatística descritiva. Resultados: Participantes: 1245 crianças, 215 participantes entre os 6-10 anos (17%); 720 entre 11-15 anos (58%) e 310 com 16 -18 anos (25%). Caucasianos: 88%; género feminino: 635 (51%). Registaram-se 16% com excesso de peso e 7% de obesos. A prevalência de HTA é de 8,4% e de PAE 12,8%. Registaram-se entre os 6-10 anos 5,6% de casos de HTA; 11-15 anos: 8,6% e 16-18 anos: 10%. Nos rapazes 10,5% tinham HTA (vs F.6,5%-p<0,001). Na raça caucasiana 8,7% apresentavam HTA, 6% na raça negra e 5,9 % entre asiáticos. As crianças com excesso de peso ou obesidade apresentaram valores mais elevados de HTA, 17% e 26% respetivamente. Discussão/Conclusão: A prevalência de HTA é elevada (8,4%) e aumenta com a idade, género masculino e nível de escolaridade mais avançado. Excesso de peso e obesidade contribuem para o aumento dos casos de HTA.
- PRESERFLO Microshunt™ versus Non-Penetrating Deep Sclerectomy for Glaucoma Management, One-Year Results.Publication . Cunha, Bruna; Gil, Pedro; Lopes, Edgar; Elisa-Luís, Maria; Reina, Maria; Gomes, Teresa; Cardigos, JoanaPurpose: To compare the short-term efficacy and safety of the PRESERFLO™ MicroShunt (PF) versus Non-Penetrating Deep Sclerectomy (NPDS) with Esnoper®. Methods: Retrospective comparative cohort study at a tertiary hospital including 79 eyes from 79 patients submitted to surgery (32 PF implantation, Group 1 and 47 NPDS, Group 2) between January 2022 and August 2023, with one year follow-up. Outcome measures included intraocular pressure (IOP), complications, surgical duration, postoperative major and minor interventions. Surgical failure was defined as IOP>21 mmHg or <20% reduction from baseline, IOP<5 mmHg, major postoperative intervention, or loss of light perception. Conversely, success was defined as the absence of these failure criteria: complete success without glaucoma medications, and qualified success with. Results: Baseline characteristics, including age, sex, IOP, number of IOP-lowering medications, and visual field defects, were comparable between groups (p>0.05). After one year, IOP decreased significantly in both groups (PF: 20.13±6.20 to 15.00±3.15 mmHg; NPDS: 19.57±5.73 to 13.30±3.59 mmHg, both p<0.001). Complete success rates were 28.1% for PF and 40.4% for NPDS (p=0.189), while surgical failure was significantly higher in the PF group (65.6% vs 38.3%, p=0.015). Major reinterventions were more frequent with PF (10 vs 3, p=0.005), partly due to encapsulated blebs, while NPDS required more minor interventions (2 vs 17, p=0.002). Complication rates were similar (31.3% vs 14.9%, p=0.073), but surgical duration was shorter in the PF group (60.03±17.95 min vs 69.91±15.23 min, p=0.008). Conclusion: PF and NPDS share comparable safety profiles. Although PF surgery is faster, it is associated with a higher rate of major postoperative interventions and failure. NPDS, while requiring more minor interventions, such as goniopuncture and needling, rarely demands major re-interventions. NPDS is known for its meticulous and technically challenging technique, but once mastered, it can result in fewer invasive re-interventions and improved efficacy.
- Impairment in Social Cognition in People With Substance Use Disorders.Publication . Piñón-Blanco, Adolfo; Rodrigues, Sonia; Teixeira, Joana; Coutinho, Catia; Faria, Isabela; Murta, Ilda; Tavares, Ana Isabel; Iglesias-Rejas, Luis; Carrera-Machado, Indalecio; Garcia-Caballero, Alejandro; Gutiérrez-Martínez, Olga; Otero-Lamas, Francisco; Spuch, CarlosIntroduction: Substance use disorders are associated with impairments in various neuropsychological functions. We evaluated potential alterations in social cognition and differences between men and women in individuals with substance use disorders undergoing treatment at Addiction and Dependency Intervention Centers in Portugal. Methods: The assessment utilized the Ekman 60 Faces Test (EFT), Interpersonal Reactivity Index (IRI), Hinting Task, and Ambiguous Intentions Hostility Questionnaire (AIHQ). Results: Results showed that 70.2% of participants exhibited social cognition impairments (50% of women and 79.5% of men). Compared to non-clinical populations, individuals with social cognition impairments displayed significant differences in recognizing emotions such as happiness, fear, sadness, disgust, anger, and in the total EFT score. Differences were also observed in the fantasy and personal distress dimensions of the IRI, as well as in hostility, intentionality, and aggression biases on the AIHQ. Slight differences were found between men and women, but were not statistically significant. Discussion: We discuss the clinical relevance of social cognition alterations and their potential utility in improving diagnostic and therapeutic processes for individuals with substance use disorders.
- Validation of a Portuguese Version of the Four-Item Migraine Interictal Burden Scale.Publication . Ferrão Malheiro, Sofia; Dourado Sotero, Filipa; Pereira, Manuel Bragança; Nunes Vicente, Beatriz; Franco, Roberto Luís Mendes; Duardte Rodrigues Casanosa, Sofia; Ramos Ferreira, Jorge Miguel; Santos Gil Gouveia, Raquel; Andrade, Carlos; Pavão Martins, IsabelBackground: Migraine is the most common neurological disorder and the second leading cause of disability. While the impact of migraine on daily life is often assessed by the frequency and intensity of attacks, the impairment between episodes is frequently overlooked. The four-item Migraine Interictal Burden Scale (MIBS-4) is a tool that can provide information and help in the evaluation of interictal disability. Objective: To adapt and validate a translated version of the MIBS-4 for the Portuguese population. Methods: A prospective, multicentric observational study was conducted between July 2023 and February 2024 in six tertiary headache centers across Portugal. The MIBS-4 was translated and back-translated to obtain a consensus version. The scale was administered to 459 patients with migraine, and its psychometric properties were assessed through correlations with established measures, including the Migraine Disability Assessment Scale (MIDAS), 12-item Short Form Survey (SF-12), and Hospital Anxiety and Depression Scale (HADS). Results: A total of 459 patients were evaluated, including 430 women (93.7%), with an average age of 45.06 years. The MIBS-4 demonstrated good internal consistency with a Cronbach's alpha of 0.84 (95% confidence interval 0.81-0.86) and significant correlations with the MIDAS (r = 0.304, p < 0.001), SF-12 (r = 0.483, p < 0.001), and HADS (r = 0.211, p < 0.001), confirming its reliability and construct validity. Conclusion: This analysis showed that the Portuguese version of the MIBS-4 showed identical psychometric properties to the original scale and can effectively assess interictal disability in patients with migraine in Portuguese speaking populations. Its validation provides a valuable tool for clinical practice and research, enabling improved assessment of migraine burden and contributing to better patient care in lusophone countries.
- Oral Anticoagulant-Related Nephropathy: a New Cause for an Old Entity.Publication . Valério, Patrícia; Soares, Elsa; Abrantes, Catarina; Góis, Mário; Sousa, Helena; Farinha, Ana; Azevedo, Ana
- Yellow Fever in South America - A Plea for Action and Call for Prevention Also in Travelers from SLAMVI, ESGITM, EVASG, ALEIMC, GEPI-SEIMC, SEMEVI, and CMTZMV-ACIN.Publication . Rodriguez-Morales, Alfonso J; Alhazmi, Abdulaziz H; Katime, Abraham; Hameed, Ahneez Abdul; Morales, Alejandra; Lepetic, Alejandro Claudio; Risquez, Alejandro; Forero-Delgadillo, Alex Julián; Holguin, Alexis; Faccini-Martínez, Álvaro A; Guerrero, Amanda; Ribeiro, Ana; Al Balushi, Asma; Taylan Ozkan, Aysegul; Rathish, Balram; Diaz, Baruch; Porras-Pedroza, Beatriz Elena; Hunsajarupan, Bhanasut; Lakatos, Botond; Álvarez-Moreno, Carlos; Torres-Martinez, Carlos Neftali; Ronnberg, Caroline; Perret, Cecilia; Wejse, Christian Morberg; Adhikari, Aayush; Popescu, Corneliu Petru; Abbara, Aula; Biscayart, Cristian; Bonilla-Aldana, D Katterine; Fasan, Daniele; Calderon, Danna; de Luna, David; Forero-Peña, David A; Costescu-Strachinaru, Diana Isabela; Mendes Pedro, Diogo; Monk, Edward J M; Iliaki, Eirini; Pontali, Emanuele; Ngbede, Emmanuel O; Farkas, Ferenc Balázs; González-Sanz, Marta; Escarrá, Florencia; Mariotti, Francesca; Norman, Francesca F; Di Gennaro, Francesco; Membrillo, Francisco Javier; Arrieta, German; Guido, Giacomo; Fuster, Ángel Viudes; Grandez-Castillo, Gustavo A; Leblebicioglu, Hakan; de Jong, Hanna K; Vargas, Hernan; Kim, Jung-Ah; Cardona-Ospina, Jaime A; Torres, Jaime R; Llenas-García, Jara; Wagenhäuser, Isabell; Oteo, José A; Gallegos Braun, Jose Francisco; Sepulveda-Arias, Juan Carlos; Hernandez, Juan Pablo; Ruíz Sáenz, Julián; Nwofe, Justin Onyebuchi; Kowalska, Justyna; Jackson, Kate E; Aykac, Kubra; Rezzonico, Leonardo Francesco; Reyes, Luis Felipe; Frallonardo, Luisa; Krone, Manuel; Malagón, Marcela Fuquen; Sempere-Alcocer, Marco A; Luque, Marco Tulio; Carlos, Maria; Del Mar Faraco Oñorbe, Maria; Segura Moreno, Marina; Lauriola, Marinella; Masana, Mario; Fernandez, Marisa; Martinez-Gutierrez, Marlen; Diaz-Menendez, Marta; Martinez, Miguel J; Cabada, Miguel Mauricio; Morante-Ruiz, Miguel; Alvarez-Martinez, Miriam J; Sandoval-Paiz, Nancy; Chávez, Nuria; Joean, Oana; Arce, Octavio; Koch, Oliver; Epaulard, Olivier; Cirit, Osman Sezer; Türkmen Recen, Özlem; Quispe, Pasesa; Guillot Passerini, Patricia Lourdes; Velikov, Petar; Hueda-Zavaleta, Miguel; Ioannou, Petros; Luga, Poleta; Rath, Rama Shankar; Echavarría, René; O'Regan, Rhea; Paggi, Riccardo; Angerami, Rodrigo N; Abbara, Salam; Mattar, Salim; Scarso, Salvatore; Gaggioli, Samuele; Verbanaz, Sergio; Fauzi, Siti Mardhiah Muhamad; Jordão, Sofia; Lloveras, Susana; Ursini, Tamara; Chaves, Tánia; Weitzel, Thomas; Orduna, Tomás; Manciulli, Tommaso; Rampling, Tommy; Acero, Victor; Lezcano, Virgilio; Moncada-Navas, Wendy Karely; Villamil-Gomez, Wilmer; Özsürekçi, Yasemin; Roque, Yori; Noreen, Nadia; Yonga, Paul; Ferrara, Pietro; Harboe, Zitta Barrella