Efavirenz Concentrations in HIV-Infected Patients With and Without Viral Hepatitis

Pereira, SA; Caixas, U; Branco, T; Germano, I; Lampreia, F; Papoila, AL; Monteiro, E

http://hdl.handle.net/10400.17/1776

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Abstract(s)

AIMS: Data on efavirenz in HIV/viral hepatitis co-infected patients is non-consensual, probably due to liver function heterogeneity in the patients included. METHODS: A case control study was performed on 27 HIV-infected patients, with controlled and homogenous markers of hepatic function, either mono-infected or co-infected with HBV/HCV, to ascertain the influence of viral hepatitis on efavirenz concentrations over a 2-year follow-up period. RESULTS: No differences were found in efavirenz concentrations between groups both during and at the end of the follow-up period: control (2.43 +/- 1.91 mg l(-1)) vs. co-infected individuals (2.37 +/- 0.37 mg l(-1)). CONCLUSION: It was concluded that HBV/HCV infections in themselves do not predispose to an overexposure to efavirenz.

Keywords

CHLC MED Doenças Hepáticas Inibidores de Transcriptase Reversa Projectos Piloto Índice de Gravidade da Doença Resultado de Tratamento Carga Viral Infecções Oportunistas Relacionadas com a SIDA Benzoxazinas Contagem de Linfócito CD4 Estudos de Casos e Controles Evolução da Doença Relação Dose-Resposta a Medicamento Monitorização de Medicamentos Estudos de Follow-Up Infecção por HIV Hepatite B Crónica Hepatite C Crónica Metabolismo