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Efavirenz Concentrations in HIV-Infected Patients With and Without Viral Hepatitis

2008Journal article Open access
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dc.contributor.authorPereira, SA
dc.contributor.authorCaixas, U
dc.contributor.authorBranco, T
dc.contributor.authorGermano, I
dc.contributor.authorLampreia, F
dc.contributor.authorPapoila, AL
dc.contributor.authorMonteiro, E
dc.date.accessioned2014-04-08T11:47:00Z
dc.date.available2014-04-08T11:47:00Z
dc.date.issued2008
dc.description.abstractAIMS: Data on efavirenz in HIV/viral hepatitis co-infected patients is non-consensual, probably due to liver function heterogeneity in the patients included. METHODS: A case control study was performed on 27 HIV-infected patients, with controlled and homogenous markers of hepatic function, either mono-infected or co-infected with HBV/HCV, to ascertain the influence of viral hepatitis on efavirenz concentrations over a 2-year follow-up period. RESULTS: No differences were found in efavirenz concentrations between groups both during and at the end of the follow-up period: control (2.43 +/- 1.91 mg l(-1)) vs. co-infected individuals (2.37 +/- 0.37 mg l(-1)). CONCLUSION: It was concluded that HBV/HCV infections in themselves do not predispose to an overexposure to efavirenz.por
dc.identifier.citationBr J Clin Pharmacol. 2008 Oct;66(4):551-5por
dc.identifier.urihttp://hdl.handle.net/10400.17/1776
dc.language.isoengpor
dc.peerreviewedyespor
dc.publisherWileypor
dc.subjectCHLC MEDpor
dc.subjectDoenças Hepáticaspor
dc.subjectInibidores de Transcriptase Reversapor
dc.subjectProjectos Pilotopor
dc.subjectÍndice de Gravidade da Doençapor
dc.subjectResultado de Tratamentopor
dc.subjectCarga Viralpor
dc.subjectInfecções Oportunistas Relacionadas com a SIDApor
dc.subjectBenzoxazinaspor
dc.subjectContagem de Linfócito CD4por
dc.subjectEstudos de Casos e Controlespor
dc.subjectEvolução da Doençapor
dc.subjectRelação Dose-Resposta a Medicamentopor
dc.subjectMonitorização de Medicamentospor
dc.subjectEstudos de Follow-Uppor
dc.subjectInfecção por HIVpor
dc.subjectHepatite B Crónicapor
dc.subjectHepatite C Crónicapor
dc.subjectMetabolismopor
dc.titleEfavirenz Concentrations in HIV-Infected Patients With and Without Viral Hepatitispor
dc.typejournal article
dspace.entity.typePublication
oaire.citation.endPage555por
oaire.citation.startPage551por
oaire.citation.titleBritish Journal of Clinical Pharmacologypor
rcaap.rightsopenAccesspor
rcaap.typearticlepor

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