Publication
Liver Depurative Techniques: A Single Liver Transplantation Center Experience
| dc.contributor.author | Rodrigues, J | |
| dc.contributor.author | Castro, S | |
| dc.contributor.author | Moya, B | |
| dc.contributor.author | Fortuna, P | |
| dc.contributor.author | Martins, A | |
| dc.contributor.author | Pereira, JP | |
| dc.contributor.author | Bento, L | |
| dc.contributor.author | Perdigoto, R | |
| dc.contributor.author | Barroso, E | |
| dc.contributor.author | Marcelino, P | |
| dc.date.accessioned | 2015-08-25T11:51:38Z | |
| dc.date.available | 2015-08-25T11:51:38Z | |
| dc.date.issued | 2015 | |
| dc.description.abstract | In a liver transplant (LT) center, treatments with Prometheus were evaluated. The main outcome considered was 1 and 6 months survival. Methods. During the study period, 74 patients underwent treatment with Prometheus; 64 were enrolled,with a mean age of 51 13 years; 47men underwent 212 treatments (mean, 3.02 per patient). The parameters evaluated were age, sex, laboratorial (liver enzymes, ammonia) and clinical (model for end-stage liver disease and Child-Turcotte-Pugh score) data. Results. Death was verified in 23 patients (35.9%) during the hospitalization period, 20 patients (31.3%) were submitted to liver transplantation, and 21 were discharged. LT was performed in 4 patients with acute liver failure (ALF, 23.7%), in 7 patients with acute on chronic liver failure (AoCLF, 43.7%), and in 6 patients with liver disease after LT (30%). Seven patients who underwent LT died (35%). In the multivariate analysis, older age (P ¼ .015), higher international normalized ratio (INR) (P ¼ .019), and acute liver failure (P ¼ .039) were independently associated with an adverse 1-month clinical outcome. On the other hand, older age (P ¼ .011) and acute kidney injury (P ¼ .031) at presentation were both related to worse 6-month outcome. For patients with ALF and AoCLF we did not observe the same differences. Conclusions. In this cohort, older age was the most important parameter defining 1- and 6-month survival, although higher INR and presence of ALF were important for 1-month survival and AKI for 6-month survival. No difference was observed between patients who underwent LT or did not have LT. | por |
| dc.identifier.citation | Transplant Proc. 2015 May;47(4):996-1000 | por |
| dc.identifier.uri | http://hdl.handle.net/10400.17/2293 | |
| dc.language.iso | eng | por |
| dc.peerreviewed | yes | por |
| dc.publisher | Elsevier | por |
| dc.subject | End Stage Liver Disease/mortality | por |
| dc.subject | End Stage Liver Disease/surgery | por |
| dc.subject | HCC CHBPT | por |
| dc.subject | HCC UCI | |
| dc.subject | Follow-Up Studies | |
| dc.subject | Liver Failure, Acute/mortality | |
| dc.subject | Liver Failure, Acute/surgery | |
| dc.subject | Liver Transplantation/methods | |
| dc.subject | Liver Transplantation/mortality | |
| dc.subject | Portugal/epidemiology | |
| dc.subject | Retrospective Studies | |
| dc.subject | Survival Rate/trends | |
| dc.subject | Time Factors | |
| dc.title | Liver Depurative Techniques: A Single Liver Transplantation Center Experience | por |
| dc.type | journal article | |
| dspace.entity.type | Publication | |
| oaire.citation.endPage | 1000 | por |
| oaire.citation.startPage | 996 | por |
| oaire.citation.volume | 47 | por |
| rcaap.rights | openAccess | por |
| rcaap.type | article | por |