Browsing by Author "Cunha, P"
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- Adenocarcinoma e Carcinóide GástricosPublication . Cunha, P; Cunha, JF; Burnay, MO; Galhordas, A; Fernandes, R; Calinas, FOs autores apresentam um caso clínico de adenocarcinoma e carcinóide gástricos síncronos. Discutem o diagnóstico de carcinóide gástrico e a sua associação a adenocarcinoma
- Effects of Acute Autonomic Modulation on Atrial Conduction Delay and Local Electrograms Duration in Paroxysmal Atrial FibrillationPublication . Oliveira, MM; Nogueira da Silva, M; Cunha, P; Ramos, R; Marques, F; Santos, S; Rocha, I; Silva-Carvalho, L; Cruz Ferreira, RSlowed atrial conduction may contribute to reentry circuits and vulnerability for atrial fibrillation (AF). The autonomic nervous system (ANS) has modulating effects on electrophysiological properties. However, complex interactions of the ANS with the arrhythmogenic substrate make it difficult to understand the mechanisms underlying induction and maintenance of AF. AIM: To determine the effect of acute ANS modulation in atrial activation times in patients (P) with paroxysmal AF (PAF). METHODS AND RESULTS: 16P (9 men; 59±14years) with PAF, who underwent electrophysiological study before AF ablation, and 15P (7 men; 58±11years) with atrioventricular nodal reentry tachycardia, without documentation or induction of AF (control group). Each group included 7P with arterial hypertension but without underlying structural heart disease. The study was performed while off drugs. Multipolar catheters were placed at the high right atrium (HRA), right atrial appendage (RAA), coronary sinus (CS) and His bundle area (His). At baseline and with HRA pacing (600ms, shortest propagated S2) we measured: i) intra-atrial conduction time (IACT, between RAA and atrial deflection in the distal His), ii) inter-atrial conduction time (interACT, between RAA and distal CS), iii) left atrial activation time (LAAT, between atrial deflection in the distal His and distal CS), iv) bipolar electrogram duration at four atrial sites (RAA, His, proximal and distal CS). In the PAF group, measurements were also determined during handgrip and carotid sinus massage (CSM), and after pharmacological blockade of the ANS (ANSB). AF was induced by HRA programmed stimulation in 56% (self-limited - 6; sustained - 3), 68.8% (self-limited - 6; sustained - 5), and 50% (self-limited - 5; sustained - 3) of the P, in basal, during ANS maneuvers, and after ANSB, respectively (p=NS). IACT, interACT and LAAT significantly lengthened during HRA pacing in both groups (600ms, S2). P with PAF have longer IACT (p<0.05), a higher increase in both IACT, interACT (p<0.01) and electrograms duration (p<0.05) with S2, and more fragmented activity, compared with the control group. Atrial conduction times and electrograms duration were not significantly changed during ANS stimulation. Nevertheless, ANS maneuvers increased heterogeneity of the local electrograms duration. Also, P with sustained AF showed longer interACT and LAAT during CSM. CONCLUSION: Atrial conduction times, electrograms duration and fractionated activity are increased in PAF, suggesting a role for conduction delays in the arrhythmogenic substrate. Acute vagal stimulation is associated with prolonged interACT and LAAT in P with inducible sustained AF and ANS modulation may influence the heterogeneity of atrial electrograms duration.
- Impacto da Terapia de Ressincronização Cardíaca na Qualidade de Vida em Doentes com Insuficiência Cardíaca Congestiva RefractáriaPublication . Nave Leal, E; Pais Ribeiro, JL; Oliveira, MM; Nogueira da Silva, M; Feliciano, J; Cunha, P; Soares, RM; Santos, S; Alves, S; Rebelo da Silva, N; Cruz Ferreira, RA terapêutica de ressincronização cardíaca (TRC), associada ou não a cardioversor-desfibrilhador, está recomendada no tratamento de doentes com insuficiência cardíaca congestiva (ICC) refractária e disfunção sistólica grave do ventrículo esquerdo, com evidência de dessíncronia. Objectivo: avaliar o impacto da TRC na qualidade de vida de doentes com ICC refractária ao tratamento farmacológico optimizado.
- Mesotelioma Peritoneal Maligno. Dificuldades Diagnósticas e TerapêuticasPublication . Cunha, P; Luz, Z; Seves, I; Sousa, C; Skiappa; Ribeiro, L; Marques, C; Oliveira, MO Mesotelioma Peritoneal Maligno (MPM) é um tumor raro, de apresentação clínica inespecífica, colocando dificuldades diagnósticas particularmente na diferenciação com carcinomatose peritoneal. O diagnóstico tardio e a ineficácia da terapêutica convencional – cirurgia, radioterapia, quimioterapia – conferem-lhe um mau prognóstico com sobrevida média de 6-12 meses. Os autores descrevem um caso de MPM diagnosticado durante investigação de ascite inaugural, através de biópsia peritoneal laparoscópica. Submetido a quimioterapia sistémica, o doente encontra-se em remissão parcial aos 42 meses.
- Trombos Intraventriculares com Embolização Sistémica: a Propósito de Dois Casos ClínicosPublication . Magno, P; Freitas, A; Cunha, P; Loureiro, J; Fragata, J; Ferreira, RA formação de trombos intraventriculares é um complicação frequente nos doentes com miocardiopatia dilatada e enfarte agudo do miocárdio, sendo o risco de embolização sistémica muito variável em função da patologia subjacente e características subjacentes dos trombos. Os autores descrevem dois casos clínicos relativos a dois doentes internados no mesmo dia com trombos intraventriculares, volumosos, protuberantes e muito móveis, no contexto de miocardiopatia dilatada e enfarte agudo do miocárdio, que embolizaram para os membros inferiores. Salientam a importância da ecocardiografia no diagnóstico, caracterização morfológica inicial e controlo evolutivo dos trombos intraventriculares, aspectos fundamentais na avaliação do risco embólico. Na ausência de recomendações específicas quanto às opções terapêuticas – anticoagulação, trombólise ou remoção cirúrgica, os autores sublinham a necessidade de avaliação individualizada, «caso a caso», tendo em conta o risco embólico, hemorrágico, e cirúrgico.
- Validation of a Heart Failure Risk Score in a Cohort of Cardiac Resynchronization Therapy Patients Under Remote Monitoring: Results from the TriageHF™ AlgorithmPublication . Cardoso, I; Cunha, P; Laranjo, S; Grazina, A; Viegas, J; Portugal, G; Valente, B; Lousinha, A; Brás, P; Brás, M; Cruz Ferreira, R; Oliveira, MThe heart failure risk status (HFRS) is a validated dynamic tool for risk score prediction, based on the TriageHF™ algorithm (Medtronic, Minneapolis, MN, USA), for the occurrence of a heart failure (HF) event in the 30 days following a remote monitoring (RM) transmission. The aim of this study was to evaluate the accuracy of the HFRS in predicting an unplanned hospital admission due to HF decompensation in a real-world cohort of patients submitted to cardiac resynchronization therapy (CRT). We conducted a single-center review of a cohort of 40 consecutive HF patients, under RM, with CRT devices using the HFRS of the TriageHF™ algorithm. The correlation of the HFRS with hospital admissions was analyzed. During a mean follow-up of 36 months, a stepwise increase in the HFRS was significantly associated with a higher risk of HF admission (odds ratio, 12.7; 95% confidence interval, 3.2-51.5; P < .001), and the HFRS was demonstrated to have good discrimination for HF hospitalization, with an area under the receiver-operating characteristic curve of 0.812. The TriageHF™ algorithm effectively predicted HF-related hospitalization in a cohort of CRT patients during long-term RM follow-up, providing a novel clinical pathway to optimize the clinical management of this complex population.