Browsing by Author "Fragata, J"
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- Acute Kidney Injury after Pediatric Cardiac Surgery: Risk Factors and Outcomes. Proposal for a Predictive ModelPublication . Cardoso, B; Laranjo, S; Gomes, I; Freitas, I; Trigo, C; Fragata, I; Fragata, J; Pinto, MFObjectives: To characterize the epidemiology and risk factors for acute kidney injury (AKI) after pediatric cardiac surgery in our center, to determine its association with poor short-term outcomes, and to develop a logistic regression model that will predict the risk of AKI for the study population. Methods: This single-center, retrospective study included consecutive pediatric patients with congenital heart disease who underwent cardiac surgery between January 2010 and December 2012. Exclusion criteria were a history of renal disease, dialysis or renal transplantation. Results: Of the 325 patients included, median age three years (1 day---18 years), AKI occurred in 40 (12.3%) on the first postoperative day. Overall mortality was 13 (4%), nine of whom were in the AKI group. AKI was significantly associated with length of intensive care unit stay, length of mechanical ventilation and in-hospital death (p<0.01). Patients’ age and postoperative serum creatinine, blood urea nitrogen and lactate levels were included in the logistic regression model as predictor variables. The model accurately predicted AKI in this population, with a maximum combined sensitivity of 82.1% and specificity of 75.4%. Conclusions: AKI is common and is associated with poor short-term outcomes in this setting. Younger age and higher postoperative serum creatinine, blood urea nitrogen and lactate levels were powerful predictors of renal injury in this population. The proposed model could be a useful tool for risk stratification of these patients.
- Adult Congenital Heart Disease: a Substrate for Infective EndocarditisPublication . Faustino, M; Freitas, A; Oliveira Soares, A; Fragata, J; Gil, V; Morais, C
- Anomalous Aortic Origin of Coronary Arteries: Early Results on Clinical Management from an International Multicenter StudyPublication . Padalino, M; Franchetti, N; Sarris, GE; Hazekamp, M; Carrel, T; Frigiola, A; Horer, J; Roussin, R; Cleuziou, J; Meyns, B; Fragata, J; Telles, H; Polimenakos, A; Francois, K; Veshti, A; Salminen, J; Rocafort, A; Nosal, M; Vedovelli, L; Protopapas, E; Tumbarello, R; Merola, A; Pegoraro, C; Motta, R; Boccuzzo, G; Sojak, V; Rito, M; Caldaroni, F; Corrado, D; Basso, C; Stellin, GBACKGROUND: Anomalous aortic origin of coronary arteries (AAOCA) is a rare abnormality, whose optimal management is still undefined. We describe early outcomes in patients treated with different management strategies. METHODS: This is a retrospective clinical multicenter study including patients with AAOCA, undergoing or not surgical treatment. Patients with isolated high coronary take off and associated major congenital heart disease were excluded. Preoperative, intraoperative, anatomical and postoperative data were retrieved from a common database. RESULTS: Among 217 patients, 156 underwent Surgical repair (median age 39 years, IQR: 15-53), while 61 were Medical (median age 15 years, IQR: 8-52), in whom AAOCA was incidentally diagnosed during screening or clinical evaluations. Surgical patients were more often symptomatic when compared to medical ones (87.2% vs 44.3%, p < 0.001). Coronary unroofing was the most frequent procedure (56.4%). Operative mortality was 1.3% (2 patients with preoperative severe heart failure). At a median follow up of 18 months (range 0.1-23 years), 89.9% of survivors are in NYHA ≤ II, while only 3 elderly surgical patients died late. Return to sport activity was significantly higher in Surgical patients (48.1% vs 18.2%, p < 0.001). CONCLUSIONS: Surgery for AAOCA is safe and with low morbidity. When compared to Medical patients, who remain on exercise restriction and medical therapy, surgical patients have a benefit in terms of symptoms and return to normal life. Since the long term-risk of sudden cardiac death is still unknown, we currently recommend accurate long term surveillance in all patients with AAOCA.
- Aortic Valve Replacement Surgery Improves the Quality of Life of Octogenarians with Severe Aortic StenosisPublication . Bento, D; Coelho, P; Lopes, J; Fragata, J
- Arteriovenous Hemangioma of the Mitral Valve: Successful Surgical Removal in an InfantPublication . Perez-Brandão, C; Carvalho, R; Pinto, MF; Fragata, J
- Assistência Ventricular em CriançasPublication . Fragata, J; Coelho, PP; Afonso, D; Nogueira, G; Trigo, C; Soares, RM; Banazol, N; Silva, N; Fragata, IDescreve-se a utilização de um sistema de assistência mecânica bi-ventricular, para-corpórea (Berlin Heart), como ponte para transplante, numa criança de dois anos, sofrendo de miocardiopatia dilatada. O período de assistência durou três meses e meio e o transplante foi bem sucedido. Descreve-se o caso clínico, os protocolos usados e revêem-se as indicações, as técnicas e os problemas com a assistência ventricular mecânica em crianças.
- Avaliação da Performance Cirúrgica: Como Fazer?Publication . Fragata, JAssessment of surgical performance is a must for every surgical practice nowadays and can be done by using scientific methods imported mostly from the Quality control tools that have been in use for long in industry. Surgical performance comprises several dimensions including clinical activity (mortality and morbidity as end points), academic activities, research and, more and more, efficiency. Stable long time results (efficacy), reducing error (safety) and meeting patient expectations (patient satisfaction) are among other performance components. This paper focus on the precise definitions of mortality and morbidity related to surgical activities and on the tools to evaluate patient complexity and assess pre operative risk. Some graphic representations are suggested to compare performance profiles of surgeons and to define individual performance profiles. Strong emphasis is put on pre operative risk assessment and its crucial role to interpret divergent surgical results. Where risk assessment is not possible or is unavailable, observed / expected ratios (O/E) for a given endpoint , be it mortality, length of stay or morbidity, must be established and routinely used to refer results and to identify performance outliers. Morbidity is being pointed out as a most valuable performance indicator in surgery because it is sensitive and comprises efficiency, safety and quality, at large.
- Carcinoma Hepatocelular Metastático: Massa Auricular Direita como Manifestação Clínica Primária. Caso ClínicoPublication . Afonso, DV; Laranjeira, A; Galrinho, A; Fragata, JNos doentes com carcinoma hepatocelular a incidência de metástases cardíacas é de 0.67-3%. Mesmo na ressecção com intuito curativo, o prognóstico é reservado, sendo a sobrevida aos 5 anos de 12-39%. Descrevemos um caso clínico, pouco habitual, de um indivíduo do sexo masculino, de 51 anos de idade, que apresentava uma massa localizada à aurícula direita, diagnosticada por exame histopatológico, como sendo metástase de um carcinoma hepatocelular, tendo sido necessária a ressecção cirúrgica urgente, devido a instabilidade cardiovascular.
- Cirurgia de Reparação Mitral em Crianças com Valvulopatia AdquiridaPublication . Fragata, J; Coelho, PP; Banazol, N; Nogueira, G; Trigo, CBACKGROUND: Valve surgery in children is aimed at restoring correct hemodynamics with few reoperations and limited resort to prostheses, which would imply early deterioration or definitive hypocoagulation. OBJECTIVES: Report a series of paediatric pts with acquired mitral valve disease, mostly due to rheumatic disease, in whom it was possible, for the great majority, to repair the damaged valve. DEMOGRAPHICS: Fifty children with predominant mitral valve disease, 47 rheumatic (94%) and 3 after endocarditis were consequently operated by the same surgical team over the last five years. Ages were 12.5+/-3.1 yrs and weights 33.2+/-8.4 Kg, 30 pts presented with predominant mitral regurgitation and 20 pts had significant stenosis. In 8 pts there also moderate to severe aortic regurgitation and in 2 pts severe tricuspid regurgitation was present. Patients were not operated during the acute phase of the disease. Five pts were reoperations and from those, all but one received mechanical prosthesis. RESULTS: In all operations the intention was to repair the mitral valve. In 46 pts complex mitral valvuloplasties were performed extended comissurotomies, shortening of chordae, chordal replacement with PTFE, and reconstruction of valve leaflefts by direct patching or pericardial extension of the retracted posterior leaflet (78.2% cases), plus reshaping of the annulus by using a fixed prosthetic CE ring (sizes 26 to 32) in every case. Ring sizes correlated poorly with body weights, but correlation was close and positive for the use of pericardial advancement of the posterior leaflet (p<0.01). There was no operative mortality, but one pt died early from sepsis and there was no late mortality. Maximum follow up extends now to 50 months (median 28 months) and functional evaluation, at latest follow up, as assessed by Doppler Echocardiography, showed residual mitral regurgitation, mild-moderate in 4 pts and LA-LV gradients mild in 5 and moderate in 2 pts. NYHA functional class, at present follow-up is class I for 43 pts (88%) and class II in the remaining 6 pts. Along the follow-up period 2 pts had to be reoperated for early repair failures and other three for late failures, presently freedom for reoperation is 91.8% at 5 years. CONCLUSIONS: Mitral valve repair in children with rheumatic lesions can be achieved for the great majority of cases by using different techniques. Pericardial extension of the retracted posterior leaflet allowed the use of a bigger size prosthetic ring. Intermediate functional results are good with fair functional classes and few reoperations but follow-up is short and does not allow us to draw conclusions about the long-term results of the repair in these rheumatic patients.