Browsing by Author "Moreira, A"
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- 0 Impacto da lnvestigação Neurofisiológica na Referenciação para Cirurgia da Epilepsia na Esclerose TuberosaPublication . Borges, D; Calado, E; Vieira, JP; Moreira, A; Leal, A; Dias, AI
- Analysis of the Dynamics and Origin of Epileptic Activity in Patients with Tuberous Sclerosis Evaluated for Surgery of EpilepsyPublication . Leal, A; Dias, AI; Vieira, JP; Moreira, A; Távora, L; Calado, EObjective: The epilepsies associated with the tuberous sclerosis complex (TSC) are very often refractory to medical therapy. Surgery for epilepsy is an effective alternative when the critical link between the localization of seizure onset in the scalp and a particular cortical tuber can be established. In this study we perform analysis of ictal and interictal EEG to improve such link. Methods: The ictal and interictal recordings of four patients with TSC undergoing surgery for epilepsy were submitted to independent component analysis (ICA), followed by source analysis, using the sLORETA algorithm. The localizations obtained for the ictal EEG and for the average interictal spikes were compared. Results: The ICA of ictal EEG produced consistent results in different events, and there was good agreement with the tubers that were successfully removed in three of the four patients (one patient refused surgery). In some patients there was a large discrepancy between the localization of ictal and interictal sources. The interictal activity produced more widespread source localizations. Conclusions: The use of ICA of ictal EEG followed by the use of source analysis methods in four cases of epilepsy and TSC was able to localize the epileptic generators very near the lesions successfully removed in surgery for epilepsy. Significance: The ICA of ictal EEG events may be a useful add-on to the tools used to establish the connection between epileptic scalp activity and the cortical tubers originating it, in patients with TSC considered for surgery of epilepsy.
- Analysis of the Generators of Epileptic Activity in Early-Onset Childhood Benign Occipital Lobe EpilepsyPublication . Leal, A; Nunes, S; Dias, AI; Vieira, JP; Moreira, A; Calado, EObjective: The Panayiotopoulos type of idiopathic occipital epilepsy has peculiar and easily recognizable ictal symptoms, which are associated with complex and variable spike activity over the posterior scalp areas. These characteristics of spikes have prevented localization of the particular brain regions originating clinical manifestations. We studied spike activity in this epilepsy to determine their brain generators. Methods: The EEG of 5 patients (ages 7–9) was recorded, spikes were submitted to blind decomposition in independent components (ICs) and those to source analysis (sLORETA), revealing the spike generators. Coherence analysis evaluated the dynamics of the components. Results: Several ICs were recovered for posterior spikes in contrast to central spikes which originated a single one. Coherence analysis supports a model with epileptic activity originating near lateral occipital area and spreading to cortical temporal or parietal areas. Conclusions: Posterior spikes demonstrate rapid spread of epileptic activity to nearby lobes, starting in the lateral occipital area. In contrast, central spikes remain localized in the rolandic fissure. Significance: Rapid spread of posterior epileptic activity in the Panayitopoulos type of occipital lobe epilepsy is responsible for the variable and poorly localized spike EEG. The lateral occipital cortex is the primary generator of the epileptic activity.
- And after the Sensory Processing Disorders? - What answers does the DSM-5 havePublication . Gomes Cano, C; Sá Machado, L; Garcia Ribeiro, C; Pires, S; Farinha, M; Moreira, A; Macieira, J; Mesquita Reis, J; Caldeira da Silva, P; Queiroga, LIntroduction: From the question of whether the diagnosis of Sensory Processing Disorder (SPD) should have classification matching in the DSM-5 or whether it constitutes a pre-morbid condition for other pathologies, a retrospective study was conducted in 2016 titled Regulatory Disturbances: The Return to the Past - Conditioners of Evolution. The study did not show a significant association between the abnormal results obtained in the SDQ scale by children with PRPS and therapeutic intervention, which allowed us to conclude that it is imperative to rethink the intervention of these cases. From these results and the lack of corresponding diagnosis in DSM-5, the present study intends to understand what possible diagnoses these children have in the latency / adolescence and adult age and what are the therapeutic interventions required. Objectives: Characterize the sample of children diagnosed with Sensory Processing Disorder who used the psychiatry consultation at the unity of infant mental health (UPI) between 2006-2013; characterize the results obtained at the follow-up; check current medical status, pharmacological therapy, other therapeutic interventions, and if they present another corresponding diagnosis in the DSM-5. Methods: Retrospective and follow-up study using the Clinical Processes of the first consultations performed between the years 2006 and 2013 at the UPI. Evaluation of the current state was made by telephone through a structured interview to the main caregivers and the application of the SDQ. The information will be submitted to statistical processing (in SPSS®), with descriptive analysis and correlation of variables. The sample is of Convenience. Results: 55 children with SPD (N=55), 47 of their caregivers answered a telephone interview (n=47). No statistically significant association was found between any SPD type and current diagnosis of ADHD nor parental perception of current state. Significant association between SPD diagnosis and abnormal results in subscales of hyperactivity (p = 0.027) and behavior problems (p = 0.017) of the SDQ. Discussion and Conclusion: The wide dispersion of diagnoses found may pose two hypotheses: SPD should be considered as an independent diagnostic category; symptomatology (alterations in the SP) can be common to different pathologies. It is important to carry out prospective studies in children diagnosed with SPD, in order to determine if it may be a future diagnostic category in the DSM.
- Autism Spectrum Disorder Secondary to Enterovirus EncephalitisPublication . Marques, F; Brito, MJ; Conde, M; Pinto, M; Moreira, AMillions of children are infected by enteroviruses each year, usually exhibiting only mild symptoms. Nevertheless, these viruses are also associated with severe and life-threatening infections, such as meningitis and encephalitis. We describe a 32-month-old patient with enteroviral encephalitis confirmed by polymerase chain reaction in cerebrospinal fluid, with unfavorable clinical course with marked developmental regression, autistic features, persistent stereotypes and aphasia. She experienced slow clinical improvement, with mild residual neurologic and developmental deficits at follow-up. Viral central nervous system infections in early childhood have been associated with autism spectrum disorders but the underlying mechanisms are still poorly understood. This case report is significant in presenting a case of developmental regression with autistic features and loss of language improving on follow-up. To our knowledge, this is the first published report of enterovirus encephalitis leading to an autism spectrum disorder.
- Défice de Ciclohidrolase (Distonia Dopa Sensìvel) Autossómica Dominante.Publication . Manita, M; Moreira, A; Calado, E; Vilarinho, L
- Different Electroclinical Manifestations of the Epilepsy Associated with Hamartomas Connecting to the Middle or Posterior HypothalamusPublication . Leal, A; Moreira, A; Robalo, C; Ribeiro, CPURPOSE: The epilepsy associated with hypothalamic hamartomas (HHs) has typical clinical, electrophysiologic, and behavioral manifestations refractory to drug therapy and with unfavorable evolution. It is well known that only sessile lesions produce epilepsy, but no correlation has been established between the different types of sessile hamartomas and the diverse manifestations of the epilepsy. We correlate anatomic details of the hamartoma and the clinical and neurophysiologic manifestations of the associated epilepsy. METHODS: HHs of seven patients with epilepsy (ages 2- 25 years) were classified as to lateralization and connection to the anteroposterior axis of the hypothalamus by using high-resolution brain magnetic resonance imaging. We correlated the anatomic classification with the clinical and neurophysiologic manifestations of the epilepsy as evaluated in long-term (24 h) video-EEG recordings. RESULTS: HHs ranged in size from 0.4 to 2.6 cc, with complete lateralization in six of seven patients. Ictal manifestations showed good correlation with the lobar involvement of ictal/interictal EEGs. These manifestations suggest the existence of two types of cortical involvement, one associated with the temporal lobe, produced by hamartomas connected to the posterior hypothalamus (mamillary bodies), and the other associated with the frontal lobe, seen in lesions connecting to the middle hypothalamus. CONCLUSIONS: A consistent clinical and neurophysiologic pattern of either temporal or frontal lobe cortical secondary involvement was found in the patients of our series. It depends on whether the hamartoma connects to the mamillary bodies (temporal lobe cases) or whether it connects to the medial hypothalamus (frontal lobe cases).
- Doenças Neuromusculares na Idade Pediátrica em Portugal - Estudo PreliminarPublication . Santos, MA; Fineza, I; Moreno, T; Cabral, P; Ferreira, JC; Lopes Silva, R; Vieira, JP; Moreira, A; Dias, AI; Calado, E; Monteiro, JP; Fonseca, MJ; Moço, C; Furtado, F; Campos, MM; Gonçallves, O; Gomes, R; Barbosa, C; Figueiroa, S; Temudo, T; Fagundes, F
- Estudo Neurosfisiológico e Imagiológico da Epilepsia na Esclerose TuberosaPublication . Leal, A; Vieira, JP; Moreira, A; Dias, AI; Calado, E
- GNAO1: a new gene to consider on early-onset childhood dystonia]Publication . Marecos, C; Duarte, S; Alonso, I; Calado, E; Moreira, A
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