Imunohemoterapia
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- Abordagem da Hemostase e Anticoagulação no Contexto da Infeção Por SARS-CoV-2Publication . Sevivas, TS; Caiado, A; Rodrigues, A; Robalo Nunes, A
- Afibrinogenémia CongénitaPublication . Pastilha, P; Coelho, L; Costa, T; Deus, G; Santos, H; Rosa, A; Barrocas, F; Braga, LOs autores apresentam o caso de uma criança com Afibrinogenémia Congénita. A propósito desta entidade revêm a literatura referindo e comentando alguns aspectos e particularidades desta rara doença da coagulação.
- Anemias Ferropénicas. Cuidados de Enfermagem na Administração de Ferro EndovenosoPublication . Barros, G; Leal, A
- Antibodies Towards High-Density Lipoprotein Components in Patients with PsoriasisPublication . Paiva-Lopes, MJ; Batuca, J; Gouveia, S; Alves, M; Papoila, AL; Delgado Alves, JPsoriasis is a chronic inflammatory immune disorder associated with an increased risk of atherosclerosis. This increased risk is not fully understood. High-density lipoproteins (HDL) play an important role in the prevention of atherosclerosis and any factors that may hamper HDL function such as anti-HDL antibodies (aHDL) might be associated with an increased cardiovascular risk. We aimed to determine whether anti-HDL antibodies (aHDL) are present in patients with psoriasis. Sixty-seven patients with psoriasis were compared with a healthy control group. Epidemiologic and clinical data were recorded. IgG and IgM aHDL, IgG anti-apolipoprotein A-I (aApoA-I), anti-apolipoprotein E (aApoE), and anti-paraoxonase 1 (aPON1) antibodies, as well as VCAM-1, IL-6, and TNF-α were assessed by ELISA. Apolipoprotein A-I (ApoA-I) and Apolipoprotein E (ApoE) were measured by immunoturbidimetric immunoassay. Patients with psoriasis had higher titers of IgG aHDL (p < 0.001), IgG aApoA-I (p = 0.001) and aApoE antibodies (p < 0.001). IgG aHDL and aApoE titers were higher in patients with severe psoriasis (p = 0.010 and p = 0.018, respectively). Multiple regression analysis, considering all clinical and biological variables, showed that aApoE, IL-6, and aPON1 are the biological variables that best explain aHDL variability. This is the first report showing the presence of aHDL, aApoA-I, and aApoE antibodies in patients with psoriasis. These antibodies were associated with increased disease severity and may contribute to the pathogenesis of atherosclerosis in psoriasis. They may fulfill the clinical need for biomarkers of cardiovascular risk associated with psoriasis that would help to stratify patients for prevention and therapeutic approaches.
- Blood Donation in the Hospital de S. José. A 11-Year Retrospective Analysis of Deferrals and ExclusionsPublication . Caiado, A; Leão, R; Espírito-Santo, DBackground: Approximately 5% of the population donates blood each year in developed countries. Recruiting and maintaining a pool of altruistic and healthy blood donors is a challenging task. Blood donation as a dynamic process must naturally co-exist with the arguably essential deferrals. Aims: To analyse a 11-year cohort of donors and blood donations in order to determine the profile of the average donor and the typical donation. Characterize the donor’s population in terms of gender, age, number of donations, most common causes for deferral and exclusion and the possible relationships between them. Establish the tendency flow of donations per year. Methods: Analysis of 95861 blood donations from 31550 donors collected between 2000 and 2010 (11 years) in the Immunohemotherapy Department of the ‘‘Centro Hospitalar Lisboa Central - Hospital de Sa˜o Jose´’’ (Lisboa, Portugal). Prior to blood donation, donors were required to fill out a form of informed consent, a questionnaire of 21 ‘‘yes or no’’ questions and were submitted to a clinical assessment and physical examination including: measurement of weight, blood pressure, pulse and capillary hemoglobin levels. Post-donation, the collected blood was tested for ALT elevation and blood-borne viral agents (HBV, HCV, HIV 1 and 2 and HTLV 1 and 2) and other infections (Treponema pallidum). Blood donors and donations were registered in a database and statistically studied in terms of: gender and age distribution, number of donations, most common causes for deferral and exclusion. The frequency of blood donations throughout the period of observation was analyzed and statistically significant relationships between the collected variables were investigated. Results: From the population of 31550 donors 61% were male and a mean age of 41.5 years (± 12.5 years) was found. From the total of 95682 blood donations collected 78% were successful while the most common causes for deferral were: donation incompatible hemoglobin levels (5% of the blood donations and 22% of deferrals), ALT elevation (3% and 14%), positive blood screening test for Treponema pallidum (1% and 6%), medication (1% and 4%), positive serological blood markers for HBV (1% and 4%), endoscopy in the previous 12 months (1% and 3%), arterial hypertension (1% and 3%), infectious conditions (1% and 3%), influenza or influenza-like symptoms (1% and 2%) and positive serological blood markers for HCV (1% and 2%). Summary/Conclusions: Several factors may have contributed to a limited number of new regular donors in the population, namely: ageing population, the alienation of the individual from the community induced by modern lifestyles and job precariousness. It is of the utmost importance to refine our blood donation campaigns according to the existing population of donors. The optimization of the blood donation potential of a population of donors must be achieved through the development of reliable and consistent screening methods. In order to appeal to new donors it is important to promote blood donations considering the profile of the regular and healthy blood donor of the existing population.
- Causas de Morte em Doentes com Hemofilia: Estudo Retrospectivo de 1979 a 2007, no Serviço de Imunohemoterapia do HSJPublication . Costa, C; Antunes, M; Diniz, MJ
- Cirurgia e Hemofilia com Inibidor: 4 Casos ClínicosPublication . Santos, A; Diniz, MJ; Antunes, M
- Cost of Immune Tolerance Induction in Hemophilia A Patients: Results from the ITER StudyPublication . Fusco, F; Gringeri, A; Scalone, L; Mantovani, L; Rocino, A; Altisent, C; Astermark, J; Diniz, MJ; Fijnvandraat, K; Klamroth, R; Lambert, T; Lavigne-Lissalde, G; Lopez Fernandez, MF; Morfini, M
- A Critical Analysis of Our Experience As Participants in an External Quality Assessment Scheme for Blood CoagulationPublication . Oliveira, V; Campos, MM; Marques, MJ; Fernandes, AI; Lopes, AM; Alves, MH; Espírito Santo, D
- Deficiência de Factor XIPublication . Conde, P; Alegria, A; Moniz, AA deficiência de factor XI é uma doença hematológica rara na população em geral. Pode manifestar-se apenas como complicação hemorrágica no doente submetido a cirurgia electiva. Os autores descrevem o caso clínico de uma mulher de 59 anos, que apresenta um quadro de hemorragia vaginal abundante 10 dias após ter sido submetida a histerectomia vaginal com McCall, plastia anterior e posterior. Salientam a importância da avaliação analítica pré-operatória, em especial o estudo da coagulação, e descrevem a abordagem e o tratamento da deficiência de factor XI.