Repository logo

IMU - Comunicações e Conferências

Permanent URI for this collection

http://hdl.handle.net/10400.17/518

Browse

Browsing IMU - Comunicações e Conferências by Title

Now showing 1 - 10 of 26
  • Blood Donation in the Hospital de S. José. A 11-Year Retrospective Analysis of Deferrals and Exclusions
    Publication . Caiado, A; Leão, R; Espírito-Santo, D
    Background: Approximately 5% of the population donates blood each year in developed countries. Recruiting and maintaining a pool of altruistic and healthy blood donors is a challenging task. Blood donation as a dynamic process must naturally co-exist with the arguably essential deferrals. Aims: To analyse a 11-year cohort of donors and blood donations in order to determine the profile of the average donor and the typical donation. Characterize the donor’s population in terms of gender, age, number of donations, most common causes for deferral and exclusion and the possible relationships between them. Establish the tendency flow of donations per year. Methods: Analysis of 95861 blood donations from 31550 donors collected between 2000 and 2010 (11 years) in the Immunohemotherapy Department of the ‘‘Centro Hospitalar Lisboa Central - Hospital de Sa˜o Jose´’’ (Lisboa, Portugal). Prior to blood donation, donors were required to fill out a form of informed consent, a questionnaire of 21 ‘‘yes or no’’ questions and were submitted to a clinical assessment and physical examination including: measurement of weight, blood pressure, pulse and capillary hemoglobin levels. Post-donation, the collected blood was tested for ALT elevation and blood-borne viral agents (HBV, HCV, HIV 1 and 2 and HTLV 1 and 2) and other infections (Treponema pallidum). Blood donors and donations were registered in a database and statistically studied in terms of: gender and age distribution, number of donations, most common causes for deferral and exclusion. The frequency of blood donations throughout the period of observation was analyzed and statistically significant relationships between the collected variables were investigated. Results: From the population of 31550 donors 61% were male and a mean age of 41.5 years (± 12.5 years) was found. From the total of 95682 blood donations collected 78% were successful while the most common causes for deferral were: donation incompatible hemoglobin levels (5% of the blood donations and 22% of deferrals), ALT elevation (3% and 14%), positive blood screening test for Treponema pallidum (1% and 6%), medication (1% and 4%), positive serological blood markers for HBV (1% and 4%), endoscopy in the previous 12 months (1% and 3%), arterial hypertension (1% and 3%), infectious conditions (1% and 3%), influenza or influenza-like symptoms (1% and 2%) and positive serological blood markers for HCV (1% and 2%). Summary/Conclusions: Several factors may have contributed to a limited number of new regular donors in the population, namely: ageing population, the alienation of the individual from the community induced by modern lifestyles and job precariousness. It is of the utmost importance to refine our blood donation campaigns according to the existing population of donors. The optimization of the blood donation potential of a population of donors must be achieved through the development of reliable and consistent screening methods. In order to appeal to new donors it is important to promote blood donations considering the profile of the regular and healthy blood donor of the existing population.
    2011Other Open access Show more
  • 2007Other Open access Show more
  • Cirurgia e Hemofilia com Inibidor: 4 Casos Clínicos
    Publication . Santos, A; Diniz, MJ; Antunes, M
    2011Other Open access Show more
  • Cost of Immune Tolerance Induction in Hemophilia A Patients: Results from the ITER Study
    Publication . Fusco, F; Gringeri, A; Scalone, L; Mantovani, L; Rocino, A; Altisent, C; Astermark, J; Diniz, MJ; Fijnvandraat, K; Klamroth, R; Lambert, T; Lavigne-Lissalde, G; Lopez Fernandez, MF; Morfini, M
    2011Other Open access Show more
  • A Critical Analysis of Our Experience As Participants in an External Quality Assessment Scheme for Blood Coagulation
    Publication . Oliveira, V; Campos, MM; Marques, MJ; Fernandes, AI; Lopes, AM; Alves, MH; Espírito Santo, D
    2018-06Journal article Open access Show more
  • Diminuição da Expressão Antigénica A Associada a Leucemia
    Publication . Santos, A; Sousa Mendes, D; Jacinto, M; Mourato, E; Rodrigues, MJ; Chabert, T
    2008Other Open access Show more
  • 2008Other Open access Show more
  • Glanzmann's Thrombastenia Treatment: a Center's Experience
    Publication . Santos, A; Antunes, M; Diniz, MJ
    2006Other Open access Show more
  • HCV Infection in Patients with Hereditary Bleeding Disorders
    Publication . Caiado, A; Antunes, M; Santos, AL; Esteves, J; Diniz, MJ
    Introduction: Hepatitis C virus (HCV) infection in patients with hereditary bleeding disorders (HBDs), as a consequence of treatment with transfusion of human bloodderived components between the late 1970s and 1980s, represents a major health concern. Objectives: Assessment and evaluation of the burden of HCV infection, its complications, and treatment in a population of patients with HBDs. Methods: Analysis of a series of 161 patients with HBDs treated in the Immunohemotherapy Service of the Centro Hospitalar de Lisboa Central (Lisboa, Portugal), consultation and systematic review of the patients clinical processes, elaboration of a database comprising the information gathered; and statistical study of its variables: age, gender, degree of severity of the bleeding disorder, treatment modality, and major and minor complications of HCV infection. Results: Sixty-five (40%) of the 161 patients have HCV infection. Among the patients with hemophilia A, 36% are severe and 62% of those have HCV infection; 9% moderate with 57%; 25% mild with 20%. In the hemophilia B group, 8% are severe with 23% infected and 6% moderate or mild with 10%. Concerning the patients with von Willebrand disease, 12% have type 2 with 16% infected and 4% have type 3 with 86%. Conclusions: HCV infection represents a very significant complication of the treatment employed in the past in the studied population. Considering that most of these patients were infected in the late 1970s and early 1980s, and the natural evolution of HCV infection in patients without bleeding disorders, it is expected that the prevalence of major complications will rise significantly in the coming years. Prophylactic measures should be implemented to enhance the follow-up protocols and prevent further development of liver damage in these patients.
    2012Other Open access Show more
  • 2004Other Open access Show more